Blood groups, blood transfusions, and blood donation

Animals also require blood transfusions in cases of significant blood loss due to accidents, surgery, coagulation disorders, and various diseases. Blood is collected from donor animals for this purpose. As with humans, animals also have different blood types that must be taken into account.

INHALT
The different blood groups Blood transfusion procedure Blood donation - Requirements and procedure
The different blood groups

Blood groups are classified based on specific surface structures on red blood cells, known as antigens.

Cats

Similar to humans, cats have blood types A, B, or C (=AB). Blood group distribution depends heavily on breed. European Shorthair cats usually have blood group A, while other breeds such as British Shorthair cats more commonly have blood group B. Cats are born with antibodies against blood group antigens other than their own. It is therefore essential to check the blood group before the first blood transfusion. Otherwise, severe incompatibility reactions may occur.

Dogs

There are a total of twelve blood groups in dogs. However, only the blood groups DEA (Dog Erythrocyte Antigen) 1.1 positive and DEA 1.1 negative are tested, as this antigen often causes blood transfusion reactions. DEA 1.1 negative dogs are considered "universal donors" because their blood does not cause incompatibility reactions in most dogs, regardless of their blood group. It is therefore used especially in time-critical emergencies.

Horse

A total of seven blood groups are known in horses (A, C, D, K, P, Q, and U). These carry different cell membrane proteins (=factors: a-i, r-k). Despite the 34 possible combinations of blood group and factor in horses, incompatibilities between donor and recipient blood are less common than in other animals or humans.

The first blood transfusion is usually unproblematic in dogs and horses, as they do not yet have antibodies against other blood group antigens as long as they have not had contact with foreign blood. An exception are mares that have had a foal with so-called neonatal isoerythrolysis (=destruction of the foal's red blood cells by the mare's antibodies). However, if possible, a compatibility test between donor and recipient blood should also be performed in dogs and horses during the first blood transfusion.

Blood transfusion procedure

A small area of skin on the recipient animal is shaved and disinfected. The donor blood is administered into the large jugular vein via a special infusion tube with an integrated blood filter.

The speed at which the transfusion is administered depends on the condition of the recipient animal. A rapid transfusion is necessary for animals with unstable circulation, heart disease, or renal insufficiency. For more stable patients, the transfusion takes up to four hours. The animal is continuously monitored during this time. Its heart and respiratory rates are checked regularly for up to 24 hours after the transfusion.

Risks of a blood transfusion

The following reactions may occur during and after a blood transfusion:

  • Fever is the most common reaction. It can occur within the first four hours, disappears on its own, and does not require treatment.
  • Shortness of breath may occur due to circulatory overload during and up to 24 hours after the transfusion. The transfusion is then stopped immediately. In addition, medications are given to reduce fluid retention.
  • An acute allergic reaction may occur during or in the first few hours after the transfusion. Skin reactions or gastrointestinal disorders may occur, as well as shortness of breath and allergic shock. The transfusion is then stopped immediately. Antiallergic medication is administered and, if necessary, measures are taken to support the circulatory system.
  • If hemolysis (=destruction of red blood cells) occurs, it is accompanied by fever, increased heart rate, shortness of breath, and even shock and clotting of the blood in the blood vessels. The transfusion is then stopped immediately and life-saving measures are initiated.
  • If infection occurs due to a blood donation containing pathogens, it is treated depending on the pathogen.

Blood donation - Requirements and procedure

Since it is costly to store large quantities of blood correctly, freshly collected blood from donor animals is usually used. Many veterinary practices keep a list of potential blood donor animals for this purpose. As these are often emergencies, owners who can bring their donor animals to the practice quickly and flexibly are in demand.

Donor animals must also meet the following requirements:

  • Fully grown, up to middle age
  • Healthy and calm temper
  • No stay in southern countries
  • Minimum weight: 20 kilograms for dogs, four kilograms for cats
  • Regularly vaccinated, dewormed, and, in the case of small animals, treated for ticks

After a general examination of the donor animal, a small amount of blood is taken. This blood sample is used to check whether the donor and recipient blood are compatible. If this is the case, a small area of skin on the neck is shaved and disinfected for the blood donation. Blood is then collected from the large jugular vein in a blood bag or, in cats, in a large syringe. The blood donation takes only 15 minutes, but longer in horses due to the amount of blood taken. The donor animal must remain still during this time. For cats and some dogs, a sedative injection is necessary for this purpose. Depending on the size of the recipient animal, the following amounts are collected:

  • for dogs: 250 to 500 milliliters
  • for cats: 10 milliliters per kilogram of the recipient cat's body weight
  • for horses: three to six liters

The removal of these amounts places little strain on the donor animals. The blood that is removed is replaced by the body within a short time. However, you should avoid putting your animal under any great strain for up to 24 hours after the blood donation. Dogs should wear a chest harness instead of a collar for a few days. The next blood donation may take place after three months at the earliest.