Tyzzer's disease – a danger to rodents

This disease is a very dangerous bacterial infection that primarily affects young rabbits, hamsters, rats, and mice and is often characterized by a peracute course that in most cases ends in the death of the animal. Other mammals can also become infected with this disease.

INHALT
Cause and transmission Symptoms Diagnosis Treatment Forecast Prophylaxis
Cause and transmission

The pathogen responsible for Tyzzer's disease is the bacterium Clostridium piliforme, also known as Bacillus piliformis , which was first described in 1917 by Professor Ernest Edward Tyzzer of Harvard Medical School.

The spores (the developmental stage of the bacterium) are stable in the environment and can remain infectious for up to two years in contaminated bedding. Transmission occurs via feed or water contaminated with feces from infected animals and via the animals' sleeping areas. After the pathogen enters the organism via the mouth or nose, it initially settles in the animal's intestinal tract, where it multiplies. The pathogen then enters the liver via the portal vein, where it causes severe inflammation. If bacteremia (spread of the pathogen in the blood) occurs, damage to the heart muscle and brain is usually the cause of rapid death.

The pathogen is also present in the intestines of healthy animals, but is in balance with the natural intestinal flora. Stress or other triggering factors (underlying diseases or drugs that suppress the immune system) can lead to excessive proliferation of Clostridia and thus to the onset of the disease.

Symptoms

The peracute form is characterized by sudden death without visible symptoms. The acute form mainly affects young animals that have just been weaned and is characterized by severe watery diarrhea, dehydration, lethargy, weakness, and loss of appetite. The majority of affected animals die after 1 to 2 days. A slightly milder, chronic form manifests itself in a dull, shaggy coat, loss of condition, loss of appetite, and emaciation. The symptoms are largely due to liver damage.

In gerbils in particular, encephalitis (brain inflammation) and associated neurological symptoms such as head tilt and balance disorders may also occur. However, there are also animals that carry the pathogen without ever showing symptoms. These animals are particularly feared by breeders, as they permanently excrete the pathogen and thus lead to its continued spread.

Diagnosis

It is not easy for veterinarians to diagnose Tyzzer's disease with certainty in living animals. In many cases, the affected animals die before a definitive diagnosis can be made. Since the bacterium lives inside the body's cells, it is almost impossible for the pathogen to multiply outside the organism. Detecting the pathogen in blood and feces often does not yield reliable results. Clostridium piliforme can only be reliably detected in tissue samples from the liver or intestines after the animal has died.

Treatment

Only if the sick animal is taken to the vet in time can treatment with special antibiotics and infusions to restore fluid balance be promising. In many cases, however, the disease is already so advanced and has already damaged the liver, heart, or other organs so severely that the medication is no longer effective and the animal cannot be helped. However, it is advisable to treat animals that have been in contact with the sick animal to prevent a possible outbreak of the disease in them.

Forecast

A certain number of animals that carry the pathogen do not become ill during their entire lives. It is assumed that these animals are resistant to the pathogen for reasons that are not yet clear. However, if the disease breaks out, the prognosis for Tyzzer's disease is poor. Many animals die before they can even be taken to a veterinarian.

Prophylaxis

Since the pathogen is widespread, occurs in the normal intestinal flora of many animals, and can survive for a very long time in the environment as a spore, comprehensive prevention is virtually impossible. However, in the event of outbreaks, thorough cleaning and disinfection of cages, enclosures, and objects with which the sick animals have come into contact can prevent or at least reduce the spread of the pathogen.

Any conditions that could cause stress, especially in young animals, should be avoided. Species-appropriate housing and feeding, as well as strict hygiene measures, can further reduce the risk of disease. By checking your animals' health daily, you increase the likelihood of detecting possible signs of disease at an early stage and getting your animal treated in time.